Prenatal ultrasound use and risk of autism spectrum disorder:
Findings from the case-control Study to Explore Early Development.
Article Source : https://pubmed.ncbi.nlm.nih.gov/
Prenatal ultrasound use and risk of autism spectrum disorder: Findings from the case-control Study to Explore Early Development.
Prenatal ultrasound use and risk of autism spectrum disorder: Findings from the case-control Study to Explore Early Development. 7-2
Prenatal ultrasound use and risk of autism spectrum disorder: Findings from the case-control Study to Explore Early Development
.1, 95% CI
Prenatal ultrasound use and risk of autism spectrum disorder: Findings from the case-control Study to Explore Early Development.
Findings from the case-control Study to Explore Early Development.
Findings from the case-control Study to Explore Early Development.
Abstract
Background: Studies evaluating the association between prenatal ultrasounds and autism spectrum disorder (ASD) have largely produced negative results. Concern remains due to the rising identification of children with ASD and ultrasound use.
Objective: To evaluate the association between prenatal ultrasound use and ASD.
Methods: We used data from the Study to Explore Early Development, a multisite case-control study of preschool-aged children with ASD implemented during
Prenatal ultrasound use and risk of autism spectrum disorder: Findings from the case-control Study to Explore Early Development.
Prenatal ultrasound use and risk of autism spectrum disorder: Findings from the case-control Study to Explore Early Development. 7-2
Prenatal ultrasound use and risk of autism spectrum disorder: Findings from the case-control Study to Explore Early Development. 12. We recruited cases from children receiving developmental
disability services and randomly selected population controls
from birth records. ASD case status was based on in-person
standardised assessments. We stratified analyses by pre-existing
maternal medical conditions and pregnancy complications associated
with increased ultrasound use (ultrasound indications) and used
logistic regression to model case status by increasing ultrasound
counts.
For pregnancies with medical record data on ultrasound timing,
we conducted supplementary tests to model associations by trimester
of exposure.
Results: Among
Findings from the case-control Study to Explore Early Development.
Prenatal ultrasound use and risk of autism spectrum disorder:
Findings from the case-control Study to Explore Early Development. 7-2
singleton pregnancies, ultrasound indications were more common for ASD cases than controls; respectively, for each group, no indications were reported for
Prenatal ultrasound use and risk of autism spectrum disorder: Findings from the case-control Study to Explore Early Development. 7-2
Findings from the case-control Study to Explore Early Development.
% and Prenatal ultrasound use and risk of autism spectrum disorder:
Findings from the case-control Study to Explore Early Development. 7-2 % of pregnancies, while ≥indications were reported for Prenatal ultrasound use
and risk of autism spectrum disorder:
Findings from the case-control Study to Explore Early Development. 12. We recruited cases from children receiving developmental
disability services and randomly selected population controls
from birth records. ASD case status was based on in-person
standardised assessments. We stratified analyses by pre-existing
maternal medical conditions and pregnancy complications
associated with increased ultrasound use (ultrasound indications)
and used logistic regression to model case status by increasing
ultrasound counts. For pregnancies with medical record data on
ultrasound timing, we conducted supplementary tests to model
associations by trimester of exposure.
Findings from the case-control Study to Explore Early Development.
% and Findings from the case-control Study to Explore Early Development.
Prenatal ultrasound use and risk of autism spectrum disorder:
Findings from the case-control Study to Explore Early
Development.1, 95% CI
Prenatal ultrasound use and risk of autism spectrum disorder: Findings from the case-control Study to Explore Early Development. 7-2
% of pregnancies. The percentage of pregnancies with multiple ultrasounds varied by case status and the presence of ultrasound indications. However, stratified regression models showed no association between increasing ultrasound counts and case status, either for pregnancies without (aOR
Findings from the case-control Study to Explore Early Development.
Prenatal ultrasound use and risk of autism spectrum disorder: Findings from the case-control Study to Explore Early Development
.1, 95% CI Findings from the case-control Study to Explore Early Development.
Prenatal ultrasound use and risk of autism spectrum disorder:
Findings from the case-control Study to Explore Early Development.
Prenatal ultrasound use and risk of autism spectrum disorder:
Findings from the case-control Study to Explore Early Development.
1, 95% CI. Trimester-specific analyses using medical record data showed no
association in any individual trimester.
Conclusions: We found no evidence that prenatal ultrasound use increases ASD risk. Study strengths included gold-standard assessments for ASD case classification, comparison of cases with controls, and a stratified sample to account for conditions associated both with increased prenatal ultrasound use and ASD.
Keywords: autism; developmental disorder; epidemiology; pregnancy complications; prenatal ultrasound.
